The purposes of this research were 1) to study the school academic administration of Rajamangala University of Technology Isan 2) to study the correlation between the administrative factors of school academic administration and the university academic administration of Rajamangala University of Technology Isan 3) to study Factors Effecting on the Administration of Academic Affairs of Rajamangala University of Technology Isan 4) to analyze the multiple regression of Factors Effecting on the Administration of Academic Affairs of Rajamangala University of Technology Isan. The sample groups were Teachers and Administrator in Rajamangala University of Technology Isan. The sample groups were 402 Teachers and Administrators selected through Simple Sampling. The research instrument was a 5 level-rating scales questionnaire with the reliabilities of part 2 and 3 were 0.89 and 0.91 respectively. The statistical Techniques employed in data analysis were percentage mean standard deviation Pearson Product Moment Correlation Coefficient and Enter and stepwise Multiple Regression Analysis by using the Computer program. The results were as follows 1. A whole and each part of the University academic administration of Rajamangala University of Technology Isan were high level. 2. The positive relationship of the administrative factors and the school academic administration of Rajamangala University of Technology Isan were high level and significantly at 0.05 3. A whole factors and each part of the academic administration of Rajamangala University of Technology Isan were high level. 4. For the forecast of best factor Enter and stepwise Multiple Regression Analysis it was found that the budget management(x5) characteristics of teachers(x2) University atmosphere(x6) the relationship between University and community (x3) Performance of administrator(x1) and the readiness of University of administration at 0.05 level significance (x4). If showed a stepwise Multiple Regression (R) of 0.80 finally the forecast for the University academic administration was at 64.40 percent. The forecast equations for the University academic administration were as follows: Equation of raw score: Y^ = 0.121+0.234(x5) +0.228(x2)0.113(x6) +0.134(x3) +0.136(x1) +0.112(x4) Equation of standard score: Z^ = 0.297(x5) +0.187(x2) +0.160(x6) +0.163(x3) +0.139(x1) +0.133(x4)