The purposes of this research were to examine quality of work life and work performance of teachers in Rajamangala Technology University of technology isan and to compare the quality of work life and work performance of teachers in Rajamangala Technology University of technology isan. Sample for the study consisted of 165 teachers in university. Data were obtained through the use of questionnaires and analyzed using descriptive statistics t-test ANOVA and sheffe. The 0.05 level of significance was chosen for the analysis. Results of this study revealed that all of the aspects of the quality of work life of teachers in were at the moderate level and work performances of teachers were at the high levels. Regarding the comparison of work life quality and work performance of teachers in Rajamangala Technology University of technology isan When classified by highest of Education there was found to be no significant difference at 0.05. The analysis of variance to compare the quality of work life regarding to teachers’ different job experience teacher’s different salary as a whole or individual revealed no significant differences.